HDL: Beyond Atheroprotection

HDL: Beyond Atheroprotection.

Decades of epidemiologic studies have firmly established the inverse relationship between HDL-cholesterol (HDL-C) levels and cardiovascular events.1 However, the resulting hypothesis that raising HDL-C levels should reduce cardiovascular disease (CVD)has been called into questionby the failure of recent trials designed to decrease CVD events, despite raising HDL-C levels with cholesteryl ester ...

HDL management: recent advances and perspectives beyond LDL reduction.

Mailing Address: Marcelo lemos Ineu • Rua Dr. Pantaleão, 233/502 97010-180 – Santa Maria, RS Brazil E-mail: [email protected] Manuscript received December 12, 2005; revised manuscript received March 24, 2006; accepted April 11, 2006. Atherosclerotic diseases are a major cause of morbidity and mortality worldwide1. Among the classic risk factors known, elevated levels of LDL-cholesterol (LD...

Atherosclerosis and Current Anti-Oxidant Strategies for Atheroprotection

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

RATIONALE CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). OBJECTIVE To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. METHODS AND RESULTS Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter...

Advances in High Density Lipoprotein Physiology: surprises,

9 *Equal contribution to this work 10 11 Running Title: HDL beyond atheroprotection 12 13 Address for reprint requests and other correspondence: Kyriakos E. Kypreos, Professor of 14 Pharmacology, Department of Pharmacology, University of Patras Medical School, 15 Panepistimioupolis, Rio, TK. 26500, Greece, Tel: +302610969120, Fax: +302610996103 16 email: [email protected] 17 Total word co...